Academic Title
Affiliation
Major Area(s) of Study
Professor in Residence UCSD Neuropsychology
E-mail
Phone
Address
lteyler@health.ucsd.edu 858-534-9451 Mail Code 0931 / 9500 Gilman Drive / La Jolla, CA 92093-0931
Website

thebrainlab.ucsd.edu

Graduate Institution

University of Pennsylvania

Research Description

Dr. Eyler’s research focuses on understanding individual differences in cognitive and emotional functioning using neurobiological measures including structural and functional brain imaging. In particular, she has examined the relationship between cognitive deficits in schizophrenia and abnormalities of brain function and how these relationships may change with age. She completed an NIMH-funded R01 project that examined whether brain structure and function appear to age more rapidly among individuals with bipolar disorder and how this related to increasing cognitive deficits with age. An ongoing longitudinal study investigates how blood-based inflammatory markers and mood variability relate to short- and long-term cognitive changes in bipolar disorder. Dr. Eyler is also a co-investigator on a grant examining accelerated biological and inflammatory aging in schizophrenia. Additionally, she serves as a co-investigator in the Autism Center of Excellence at UCSD studying how neuroimaging measures in infants and toddlers at risk for autism can be used to predict language outcomes. Dr. Eyler additionally is a co-investigator on the Vietnam Era Twin Study of Aging MRI study which aims to understand genetic and environmental contributions to brain aging, and she is a co-investigator and lead neuroimaging researcher at UCSD on the Meditation, Education, and Exercise (MEDEX) study, a multi-site clinical trial to improve cognitive and brain health among older adults. She also has an interest in healthy aging and has conducted studies examining the relationship of cognitive and emotional success to brain function among healthy seniors.

Representative Publications
  • Solso, S., Xu, R., Proudfoot, J., Hagler, D. J. Jr., Campbell, K., Venkatraman, V., Carter Barnes, C., Ahrens-Barbeau, C., Pierce, K., Dale, A., Eyler, L. T., & Courchesne, E [LE and EC are co-equal senior authors]. (2016). Diffusion tensor imaging provides evidence of possible axonal overconnectivity in frontal lobes in autism spectrum disorder toddlers. Biol Psychiatry, 79(8), 676-84.

  • Nguyen, T. T., Kovacevic, S., Dev, S. I., Lu, K., Liu, T. T., & Eyler, L. T. (2017). Dynamic functional connectivity in bipolar disorder is associated with executive function and processing speed: A preliminary study. Neuropsychology, 31(1), 73-83.

  • Dev, S. I., Nguyen, T. T., McKenna, B. S., Sutherland, A. N., Bartsch, H., Theilmann, R. J., & Eyler, L. T. (2017). Steeper slope of age-related changes in white matter microstructure and processing speed in bipolar disorder. American Journal of Geriatric Psychiatry. Advance online publication. doi: 10.1016/j.jagp.2017.02.014.

Collaborators

Eric Courchesne / Anders Dale / Colin Depp / Dilip Jeste / William Kremen / Karen Pierce / Julie Wetherell